Combined lifestyle factors and the risk of LADA and type 2 diabetes – Results from a Swedish population-based case-control study

AimsWe investigated the risk of latent autoimmune diabetes in adults (LADA) and type 2 relation to a healthy lifestyle, proportion patients attributable an unhealthy influence family history (FHD) genetic susceptibility.MethodsThe population-based study included incident LADA (n = 571), 1962), matched controls 2217). A lifestyle was defined by BMI < 25 kg/m2, moderate-to-high physical activity, diet, no smoking, moderate alcohol consumption. We estimated odds ratios (OR) with 95% confidence intervals (CIs) adjusted for age, sex, education, FHD.ResultsCompared poor/moderate associated reduced (OR 0.51, CI 0.34–0.77) 0.09, 0.05–0.15). conferred irrespective FHD high-risk HLA genotypes. Having kg/m2 largest reduction both 0.54, 0.43–0.66) 0.12, 0.10–0.15) out individual items.ConclusionPeople especially body weight, have including those susceptibility diabetes.